← Startups in San Francisco

San Francisco B2B 520 startups

"B2B" Startups in San Francisco

Every active San Francisco startup we index that carries the "B2B" tag.

All startups in San Francisco → "B2B" startups nationwide →

Last updated

2026-09-02

Hiring right now 6% 33 of 520

Open roles 945

City San Francisco

Our index currently lists 520 tech startups in San Francisco tagged "B2B" — a city×tag slice of the live directory, not every "B2B" company nationwide and not every San Francisco startup regardless of tag. 6% of this slice is hiring right now (33 of 520). Apply links on each profile go to the company's own site; we don't act as a middleman. "B2B" startups in San Francisco include PostHog, Accord, AfterQuery, Algolia, and Amplitude. Categories represented here: AI / ML, Dev Tools, and Healthcare. YC batches in this slice: Sp26, S26, S24, and W24, among others. Widen the view anytime: all San Francisco startups at /startups/location/san-francisco, or every "B2B" company nationwide at /startups/tag/b2b.

The single platform to analyze, test, observe, and deploy new features

Developer ToolsB2BOpen Source

The Revenue Excellence Platform

Applied research lab curating data solutions for foundation model…

Artificial IntelligenceB2BData Labeling

A developer-friendly and enterprise-grade search API.

Developer ToolsSaaSB2B

Digital Analytics Platform

Developer ToolsB2BAnalytics

All-in-one recruiting platform that empowers hiring excellence in…

Human ResourcesB2BRecruiting

Unlocking the power of biotech with modern software for modern science

The leader in automated data movement

SaaSB2BAnalytics

Provides growing businesses with everything to take care of their team

B2BPayrollHealth Insurance

Revenue Activation Platform

AI-Enhanced LearningB2BSales

Mixpanel is event analytics for builders that need answers.

B2BAnalyticsData Visualization

Vanta—the proven leader in automated compliance helping startups…

B2BComplianceSecurity

Transforming how health systems optimize labor

SaaSB2BHealthcare

The easiest way to automate your work.

SaaSB2BAutomation

Collaborative workspace for patent litigators

SaaSB2BLegalTech

The AI-native platform for next-generation protein characterization.

Artificial IntelligenceSaaSB2B

Real-time AI Compliance for Medical Documentation

Health TechB2BCompliance

AI Affiliate Network For Financial Companies

Artificial IntelligenceSaaSB2B

AI Financial Operations for Construction

SaaSConstructionB2B

B2B debt collection powered by AI agents

Artificial IntelligenceFintechB2B

The control plane for AI agents.

Artificial IntelligenceB2BIdentity

AI-powered Global Compliance Platform

FintechB2BIdentity

AI sales prospecting. Replace your SDR with AiSDR

Artificial IntelligenceSaaSB2B

Autonomous Customer Operations

Artificial IntelligenceDeveloper ToolsB2B

The Github For Coding Agents

Artificial IntelligenceGenerative AISaaS

Your AI recruiter for interviewing and identifying the best talent

SaaSB2BRecruiting

AI Native Shopify

Generative AIB2BE-commerce

OpenRouter for Agent Capabilities

Artificial IntelligenceMarketplaceB2B

AI for researchers

Artificial IntelligenceConsumerB2B

Faster clinical documentation for home health nurses

Artificial IntelligenceSaaSHealth Tech

AI-Powered Product Data Enrichment

Artificial IntelligenceMachine LearningSaaS

Apptimize lets mobile teams innovate faster to create an amazing user…

AI water leak detection for buildings

Banking & Funding for Startups

Banking as a ServiceFintechB2B

SaaSConstructionB2B

AI-native internal audit firm

Medical coding automation

SaaSHealth TechB2B

AI workers for the logistics industry.

Artificial IntelligenceGenerative AIB2B

A search technology that actually finds what you’re looking for.

Artificial IntelligenceMachine LearningSaaS

The AI BDR for enterprise revenue teams, plus a full AI sales team

Artificial IntelligenceB2BSales

The integration layer for healthcare: EHRs, payer portals & more

Artificial IntelligenceRobotic Process AutomationHealth Tech

Modern customer support platform replacement for Intercom and Zendesk

SaaSB2BCustomer Success

AI Agents for Analog Circuit Design

Generative AIReinforcement LearningB2B

One-Stop Shop for Convenience Store Inventory

MarketplaceSaaSB2B

Desktop RPA with AI computer use

Artificial IntelligenceDeep LearningB2B

AI native real-estate appraisal firm

AI agents for E2E testing across mobile & web

Artificial IntelligenceDeveloper ToolsB2B

Simulations of real people for market research

Artificial IntelligenceB2BMarketing

Showing 48 of 520 Filter the directory by this slice →

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2 of 4 similar companies are hiring right now · most common: Engineering

A foundation model for physics.

Build in a weekend. Scale to millions.

Developer ToolsOpen SourceBig Data

Generative AI for frontline worker hiring

MarketplaceRecruiting

Platform for global logistics.

SaaSLogisticsSupply Chain

All startups in San FranciscoEvery tag "B2B" startups nationwideEvery city "Artificial Intelligence" startups in San Francisco606 startups "AI" startups in San Francisco572 startups "SaaS" startups in San Francisco428 startups "Developer Tools" startups in San Francisco307 startups "Fintech" startups in San Francisco180 startups "B2B" startups in New York City144 startups "Generative AI" startups in San Francisco137 startups "Consumer" startups in San Francisco120 startups

Frequently asked questions

How many "B2B" startups are in San Francisco?

Our index currently tracks 520 active tech startups in San Francisco tagged "B2B". Counts move as scrapers discover new companies and flag shutdowns inactive.

Which "B2B" startups are based in San Francisco?

Companies on this page include PostHog, Accord, and AfterQuery, plus 517 more below. Each profile links to the company's site and any open roles we scrape.

How is this different from the San Francisco startups page or the "B2B" tag page?

/startups/location/san-francisco lists every indexed startup in San Francisco across tags. /startups/tag/b2b lists every "B2B" startup nationwide. This page is the intersection — only companies that resolve to both San Francisco and "B2B".

Are these San Francisco "B2B" startups hiring?

33 of the 520 companies on this page currently have open roles in our jobs index.

How often is this list updated?

Automated scrapers refresh on the same daily cadence as the rest of the directory. The last index update was 2026-09-02.